Gene

clic2

ID

ZDB-GENE-040718-299

Name

chloride intracellular channel 2

Symbol

clic2 Nomenclature History

Previous Names

zgc:92762

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within glutathione metabolic process; monoatomic ion transport; and regulation of monoatomic ion transmembrane transport. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including blood; cardiovascular system; macrophage; mesoderm; and neuromast. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Orthologous to human CLIC2 (chloride intracellular channel 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92762 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With clic2 Human Ortholog

No data available

Associated With clic2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010987	Glutathione S-transferase, C-terminal-like
Domain	IPR030253	Chloride intracellular channel protein 2, C-terminal domain
Domain	IPR053823	CLIC, N-terminal domain
Family	IPR002946	Intracellular chloride channel
Family	IPR040079	Glutathione transferase family
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily
Homologous_superfamily	IPR036282	Glutathione S-transferase, C-terminal domain superfamily