Gene
tk2
- ID
- ZDB-GENE-040718-243
- Name
- thymidine kinase 2
- Symbol
- tk2 Nomenclature History
- Previous Names
-
- zgc:100948
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable deoxynucleoside kinase activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process and phosphorylation. Predicted to be active in mitochondrion. Is expressed in exocrine pancreas and pectoral fin. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146682 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 | Alliance | ?Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 | 617069 |
| mitochondrial DNA depletion syndrome 2 | Alliance | Mitochondrial DNA depletion syndrome 2 (myopathic type) | 609560 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deoxynucleoside kinase domain | Deoxyribonucleoside Kinase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|
|
UniProtKB:A0A8M1N0Z5
|
268 |
Interactions and Pathways
No data available
Plasmids
No data available