Gene

sbf1

ID

ZDB-GENE-040718-139

Name

SET binding factor 1

Symbol

sbf1 Nomenclature History

Previous Names

wu:fj45d12
zgc:92634 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have phosphatase regulator activity. Predicted to be involved in regulation of GTPase activity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B3. Orthologous to human SBF1 (SET binding factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92634 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sbf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4B3	Alliance	Charcot-Marie-Tooth disease, type 4B3	615284

Associated With sbf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001194	cDENN domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR004182	GRAM domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR010569	Myotubularin-like, phosphatase domain
Domain	IPR022096	SBF1/SBF2 domain
Domain	IPR037516	Tripartite DENN domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe

Domain Details Per Protein

Protein	Length	cDENN domain	dDENN domain	DENN domain, C-terminal lobe	GRAM domain	Myotubularin-like, phosphatase domain	PH-like domain superfamily	Pleckstrin homology domain	Protein-tyrosine phosphatase-like	SBF1/SBF2 domain	Tripartite DENN domain	uDENN domain
UniProtKB:A0A8M3ARB7 InterPro	1926
UniProtKB:A0A2R8PWA9 InterPro	1936
UniProtKB:A0A8M2BBQ3 InterPro	1918
UniProtKB:F1QFF3 InterPro	1883
UniProtKB:A0A8M2BBZ8 InterPro	1908
UniProtKB:A0A8M3B8V9 InterPro	1911
UniProtKB:Q1LXZ0 InterPro	1849

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sbf1-201 (1) Ensembl	Ensembl	10,035 nt	Select Tool ZFIN BLAST
mRNA	sbf1-202 (1) Ensembl	Ensembl	7,372 nt	Select Tool
mRNA	sbf1-205 (1) Ensembl	Ensembl	10,065 nt	Select Tool ZFIN BLAST
ncRNA	sbf1-002 (1) Ensembl	Ensembl	646 nt	Select Tool
ncRNA	sbf1-003 (1) Ensembl	Ensembl	1,771 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations