Gene
gnb3a
- ID
- ZDB-GENE-040718-134
- Name
- guanine nucleotide binding protein (G protein), beta polypeptide 3a
- Symbol
- gnb3a Nomenclature History
- Previous Names
-
- gnb3l
- zgc:92641
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in nervous system. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92641 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010469Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| re21 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa9308 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12105 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital stationary night blindness 1H | Alliance | Night blindness, congenital stationary, type 1H | 617024 |
| essential hypertension | Alliance | {Hypertension, essential, susceptibility to} | 145500 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001632 | G-protein, beta subunit |
| Family | IPR016346 | Guanine nucleotide-binding protein, beta subunit |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | G-protein, beta subunit | G-protein beta WD-40 repeat | Guanine nucleotide-binding protein, beta subunit | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DH55
|
340 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-66F2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-69G19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-197A20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92641 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002437 (1) | 1964 nt | ||
| Genomic | GenBank:CT027619 (1) | 182366 nt | ||
| Polypeptide | UniProtKB:Q6DH55 (1) | 340 aa |
- Liu, X., Han, S., Liu, F., Yu, S., Qin, Y., Li, J., Jia, D., Gao, P., Chen, X., Tang, Z., Liu, M., Huang, Y. (2023) Retinal degeneration in rpgra mutant zebrafish. Frontiers in cell and developmental biology. 11:11699411169941
- Quint, W.H., Tadema, K.C.D., Kokke, N.C.C.J., Meester-Smoor, M.A., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2023) Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Scientific Reports. 13:20172017
- Ogawa, Y., Corbo, J.C. (2021) Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports. 11:17340
- Petit, J., Bailey, E.C., Wheeler, R.T., de Oliveira, C.A.F., Forlenza, M., Wiegertjes, G.F. (2019) Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway. Frontiers in immunology. 10:280
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
- Gore, A.V., Tomins, K.A., Iben, J., Ma, L., Castranova, D., Davis, A.E., Parkhurst, A., Jeffery, W.R., Weinstein, B.M. (2018) An epigenetic mechanism for cavefish eye degeneration. Nature ecology & evolution. 2(7):1155-1160
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lu, Z., Hu, X., Liu, F., Soares, D.C., Liu, X., Yu, S., Gao, M., Han, S., Qin, Y., Li, C., Jiang, T., Luo, D., Guo, A.Y., Tang, Z., Liu, M. (2017) Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Scientific Reports. 7:46098
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Lagman, D., Callado-Pérez, A., Franzén, I.E., Larhammar, D., Abalo, X.M. (2015) Transducin Duplicates in the Zebrafish Retina and Pineal Complex: Differential Specialisation after the Teleost Tetraploidisation. PLoS One. 10:e0121330
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