Gene

otub1a

ID

ZDB-GENE-040718-108

Name

OTU deubiquitinase, ubiquitin aldehyde binding 1a

Symbol

otub1a Nomenclature History

Previous Names

otub1l
fb17f04 (1)
wu:fb17f04 (1)
zgc:92685

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have NEDD8-specific protease activity; thiol-dependent ubiquitin-specific protease activity; and ubiquitin binding activity. Predicted to be involved in protein K48-linked deubiquitination. Predicted to localize to nucleus. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92685 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tse et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With otub1a Human Ortholog

No data available

Associated With otub1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003323	OTU domain
Family	IPR016615	Ubiquitin thioesterase Otubain
Family	IPR019400	Peptidase C65, otubain
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily
Homologous_superfamily	IPR042467	Peptidase C65, otubain, subdomain 2
Homologous_superfamily	IPR042468	Peptidase C65, otubain, subdomain 1

Domain Details Per Protein

Protein	Length	OTU domain	Papain-like cysteine peptidase superfamily	Peptidase C65, otubain	Peptidase C65, otubain, subdomain 1	Peptidase C65, otubain, subdomain 2	Ubiquitin thioesterase Otubain
UniProtKB:Q6DH16 InterPro	267

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	otub1a-201 (1) Ensembl	Ensembl	1,169 nt	Select Tool
mRNA	otub1a-204 (1) Ensembl	Ensembl	792 nt	Select Tool
ncRNA	otub1a-002 (1) Ensembl	Ensembl	532 nt	Select Tool
ncRNA	otub1a-003 (1) Ensembl	Ensembl	566 nt	Select Tool
ncRNA	otub1a-005 (1) Ensembl	Ensembl	517 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations