Gene
rbpms2a
- ID
- ZDB-GENE-040718-106
- Name
- RNA binding protein, mRNA processing factor 2a
- Symbol
- rbpms2a Nomenclature History
- Previous Names
-
- zgc:92689
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within female sex differentiation; neuron projection morphogenesis; and regulation of retinal ganglion cell axon guidance. Predicted to be located in cytoplasm. Is expressed in cardiovascular system; gut; pleuroperitoneal region; retina; and ventral mesoderm. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92689 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kaufman et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RBPMS2, RNA recognition motif | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PUW5
|
250 | ||||
|
UniProtKB:A0A8M9PYB9
|
255 | ||||
|
UniProtKB:A0A8M2B9Y7
|
204 | ||||
|
UniProtKB:A0A8M3AWB5
|
216 | ||||
|
UniProtKB:A0A8M9PGS4
|
267 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rbpms2a-201
(1)
|
Ensembl | 1,442 nt | ||
| mRNA |
rbpms2a-202
(1)
|
Ensembl | 4,834 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250A19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-275P19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92689 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173847 | ZFIN Curated Data |
1 - 4 of 4
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002409 (1) | 1451 nt | ||
| Genomic | GenBank:BX296538 (1) | 192787 nt | ||
| Polypeptide | UniProtKB:A0A8M9PGS4 (1) | 267 aa |
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Akerberg, A.A., Trembley, M., Butty, V., Schwertner, A., Zhao, L., Beerens, M., Liu, X., Mahamdeh, M., Yuan, S., Boyer, L., MacRae, C., Nguyen, C., Pu, W.T., Burns, C.E., Burns, C.G. (2022) RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circulation research. 131(12):980-1000
- Romano, S., Kaufman, O.H., Marlow, F.L. (2020) Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2a/b. Development (Cambridge, England). 147(18):
- Akerberg, A.A., Burns, C.E., Burns, C.G. (2019) Exploring the Activities of RBPMS Proteins in Myocardial Biology. Pediatric Cardiology. 40(7):1410-1418
- Kaufman, O.H., Lee, K., Martin, M., Rothhämel, S., Marlow, F.L. (2018) rbpms2 functions in Balbiani body architecture and ovary fate. PLoS Genetics. 14:e1007489
- van Rooij, F.J., Qayyum, R., Smith, A.V., Zhou, Y., Trompet, S., Tanaka, T., Keller, M.F., Chang, L.C., Schmidt, H., Yang, M.L., Chen, M.H., Hayes, J., Johnson, A.D., Yanek, L.R., Mueller, C., Lange, L., Floyd, J.S., Ghanbari, M., Zonderman, A.B., Jukema, J.W., Hofman, A., van Duijn, C.M., Desch, K.C., Saba, Y., Ozel, A.B., Snively, B.M., Wu, J.Y., Schmidt, R., Fornage, M., Klein, R.J., Fox, C.S., Matsuda, K., Kamatani, N., Wild, P.S., Stott, D.J., Ford, I., Slagboom, P.E., Yang, J., Chu, A.Y., Lambert, A.J., Uitterlinden, A.G., Franco, O.H., Hofer, E., Ginsburg, D., Hu, B., Keating, B., Schick, U.M., Brody, J.A., Li, J.Z., Chen, Z., Zeller, T., Guralnik, J.M., Chasman, D.I., Peters, L.L., Kubo, M., Becker, D.M., Li, J., Eiriksdottir, G., Rotter, J.I., Levy, D., Grossmann, V., Patel, K.V., Chen, C.H., Ridker, P.M., Tang, H., Launer, L.J., Rice, K.M., Li-Gao, R., Ferrucci, L., Evans, M.K., Choudhuri, A., Trompouki, E., Abraham, B.J., Yang, S., Takahashi, A., Kamatani, Y., Kooperberg, C., Harris, T.B., Jee, S.H., Coresh, J., Tsai, F.J., Longo, D.L., Chen, Y.T., Felix, J.F., Yang, Q., Psaty, B.M., Boerwinkle, E., Becker, L.C., Mook-Kanamori, D.O., Wilson, J.G., Gudnason, V., O'Donnell, C.J., Dehghan, A., Cupples, L.A., Nalls, M.A., Morris, A.P., Okada, Y., Reiner, A.P., Zon, L.I., Ganesh, S.K. (2017) Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. American journal of human genetics. 100(1):51-63
- Hörnberg, H., Cioni, J.M., Harris, W.A., Holt, C.E. (2016) Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:12697-12706
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
- Hörnberg, H., Wollerton-van Horck, F., Maurus, D., Zwart, M., Svoboda, H., Harris, W.A., and Holt, C.E. (2013) RNA-Binding Protein Hermes/RBPMS Inversely Affects Synapse Density and Axon Arbor Formation in Retinal Ganglion Cells In Vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(25):10384-10395
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