Gene

cpsf1

ID

ZDB-GENE-040709-2

Name

cleavage and polyadenylation specific factor 1

Symbol

cpsf1 Nomenclature History

Previous Names

wu:fb24c01

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable nucleic acid binding activity. Acts upstream of or within definitive hemopoiesis; mRNA polyadenylation; and retinal ganglion cell axon guidance. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Is expressed in brain; gut; head; and pectoral fin. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6894052 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpsf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopia 27	618827

Associated With cpsf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Domain	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Family	IPR050358	RSE1/DDB1/CFT1/CPSF1
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily

Domain Details Per Protein

Protein	Length	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	RSE1/DDB1/CFT1/CPSF1	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M1NHR0 InterPro	1449
UniProtKB:F6NXE7 InterPro	1448

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpsf1-201 (1) Ensembl	Ensembl	4,746 nt	Select Tool ZFIN BLAST
mRNA	cpsf1-202 (1) Ensembl	Ensembl	4,356 nt	Select Tool ZFIN BLAST
mRNA	cpsf1-203 (1) Ensembl	Ensembl	1,203 nt	Select Tool ZFIN BLAST
mRNA	cpsf1-204 (1) Ensembl	Ensembl	4,825 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations