Gene

syk

ID
ZDB-GENE-040702-3
Name
spleen tyrosine kinase
Symbol
syk Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to localize to cytoplasm. Orthologous to human SYK (spleen associated tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Christie et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With syk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency 82 with systemic inflammation 619381
Associated With syk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR035838 SYK/ZAP-70, N-terminal SH2 domain
Family IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
Family IPR050198 Non-receptor tyrosine kinases involved in cell signaling
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Non-receptor tyrosine kinases involved in cell signaling Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SYK/ZAP-70, N-terminal SH2 domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, non-receptor SYK/ZAP-70 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
UniProtKB:E9QFU7 585
UniProtKB:A0A8M2B201 608
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA syk-201 (1) Ensembl 2,167 nt
mRNA syk-202 (1) Ensembl 2,967 nt
mRNA syk-203 (1) Ensembl 5,021 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations