Gene
dlg4b
- ID
- ZDB-GENE-040628-3
- Name
- discs, large homolog 4b (Drosophila)
- Symbol
- dlg4b Nomenclature History
- Previous Names
-
- dlg4
- PSD95/SAP90 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Predicted to be involved in AMPA glutamate receptor clustering; chemical synaptic transmission; and postsynaptic neurotransmitter receptor diffusion trapping. Located in synapse. Is expressed in nervous system and neural tube. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from America et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal dominant 62 | 618793 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR015143 | L27-1 |
| Domain | IPR019583 | Disks large homolog 1-4, PDZ-associated domain |
| Domain | IPR019590 | Disks large homologue 1, N-terminal PEST domain |
| Family | IPR016313 | Disks large 1-like |
| Family | IPR050614 | Synaptic Scaffolding LAP/MAGUK Families |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
| Protein | Length | Disks large 1-like | Disks large homolog 1-4, PDZ-associated domain | Disks large homologue 1, N-terminal PEST domain | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27-1 | L27 domain | L27 domain superfamily | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Synaptic Scaffolding LAP/MAGUK Families |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6R005
|
801 |
Interactions and Pathways
No data available
Plasmids
No data available