Gene

eif2b1

ID

ZDB-GENE-040625-25

Name

eukaryotic translation initiation factor 2B, subunit 1 alpha

Symbol

eif2b1 Nomenclature History

Previous Names

zgc:86660

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6894278 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif2b1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
leukoencephalopathy with vanishing white matter 1	Alliance	Leukoencephalopathy with vanishing white matter 1, with or without ovarian failure	603896

Associated With eif2b1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000649	Initiation factor 2B-related
Family	IPR051501	Eukaryotic initiation factor 2B subunits alpha/beta/delta
Homologous_superfamily	IPR037171	NagB/RpiA transferase-like
Homologous_superfamily	IPR042528	Translation initiation factor eIF-2B subunit alpha, N-terminal
Homologous_superfamily	IPR042529	Initiation factor 2B-like, C-terminal