Gene
ptges3b
- ID
- ZDB-GENE-040625-144
- Name
- prostaglandin E synthase 3b (cytosolic)
- Symbol
- ptges3b Nomenclature History
- Previous Names
-
- fb50a04
- wu:fb50a04
- zgc:86751
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable Hsp90 protein binding activity; chaperone binding activity; and prostaglandin-E synthase activity. Predicted to be involved in several processes, including prostaglandin biosynthetic process; protein-containing complex assembly; and telomere maintenance via telomerase. Predicted to be active in cytosol and nucleus. Orthologous to human PTGES3 (prostaglandin E synthase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cacialli et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Co-chaperone protein p23-like | CS domain | HSP20-like chaperone |
|---|---|---|---|---|
|
UniProtKB:Q6IQI3
|
158 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptges3b-201
(1)
|
Ensembl | 991 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-56F13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-147F12 | ZFIN Curated Data | |
| Contains | SNP | rs3729459 | ZFIN Curated Data | |
| Encodes | EST | bn0aa016zb12 | ZFIN Curated Data | |
| Encodes | EST | fb50a04 | ||
| Encodes | cDNA | MGC:86751 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002137 (1) | 1023 nt | ||
| Genomic | GenBank:CR450824 | 170611 nt | ||
| Polypeptide | UniProtKB:Q6IQI3 (1) | 158 aa |
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Crespo, D., Lemos, M.S., Zhang, Y.T., Safian, D., Norberg, B., Bogerd, J., Schulz, R. (2019) PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen. The Journal of endocrinology. 244(1):163-175
- Morais, R.D.V.S., Crespo, D., Nóbrega, R.H., Lemos, M.S., van de Kant, H.J.G., de França, L.R., Male, R., Bogerd, J., Schulz, R.W. (2017) Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh. Molecular and Cellular Endocrinology. 454:112-124
- Crespo, D., Assis, L.H., Furmanek, T., Bogerd, J., Schulz, R.W. (2016) Expression profiling identifies Sertoli and Leydig cell genes as Fsh targets in adult zebrafish testis. Molecular and Cellular Endocrinology. 437:237-251
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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