Gene
dguok
- ID
- ZDB-GENE-040625-14
- Name
- deoxyguanosine kinase
- Symbol
- dguok Nomenclature History
- Previous Names
-
- zgc:86625
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable deoxynucleoside kinase activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6892866 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3123 | Allele with one delins | Exon 3 | Frameshift, Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 | Alliance | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 | 617070 |
| mitochondrial DNA depletion syndrome 3 | Alliance | Mitochondrial DNA depletion syndrome 3 (hepatocerebral type) | 251880 |
| Portal hypertension, noncirrhotic, 1 | 617068 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deoxynucleoside kinase | Deoxynucleoside kinase domain | Deoxyribonucleoside Kinase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q805
|
181 | ||||
|
UniProtKB:A5WUY2
|
269 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112B19 | ||
| Contained in | BAC | CH211-275J6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-204G14 | ||
| Encodes | EST | IMAGE:6892866 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86625 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173877 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100091 (1) | 1182 nt | ||
| Genomic | GenBank:CR925780 (1) | 166407 nt | ||
| Polypeptide | UniProtKB:A5WUY2 (1) | 269 aa |
- Munro, B., Horvath, R., Müller, J.S. (2018) Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish. Human molecular genetics. 28(5):796-803
- Wong, Q.W., Sun, M.A., Lau, S.W., Parsania, C., Zhou, S., Zhong, S., Ge, W. (2017) Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Biology of reproduction. 98(1):42-53
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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