Gene
tpm2
- ID
- ZDB-GENE-040625-114
- Name
- tropomyosin 2 (beta)
- Symbol
- tpm2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Localizes to striated muscle thin filament. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Orthologous to human TPM2 (tropomyosin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb836 (16 images)
- IMAGE:6892450 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 1A | 108120 |
| distal arthrogryposis type 1A | Alliance | Arthrogryposis, distal, type 2B4 | 108120 |
| nemaline myopathy 4 | Alliance | Congenital myopathy 23 | 609285 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|
|
UniProtKB:A0A8M2B1Q6
|
284 | ||
|
UniProtKB:A0A8M2B1K3
|
284 | ||
|
UniProtKB:A0A8M2B255
|
248 | ||
|
UniProtKB:A0A8M2B1Q8
|
248 | ||
|
UniProtKB:A0A8M2B2D1
|
248 | ||
|
UniProtKB:Q6IQD7
|
284 | ||
|
UniProtKB:A0A0R4IAL5
|
248 | ||
|
UniProtKB:A0A0R4IM99
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available