Gene

nf2b

ID

ZDB-GENE-040622-3

Name

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor b

Symbol

nf2b Nomenclature History

Previous Names

nf2 (1)
NF2a

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of early endosome to late endosome transport; positive regulation of protein localization to early endosome; and regulation of gliogenesis. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in several cellular components, including adherens junction; apical part of cell; and filopodium. Used to study choledochal cyst. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma (multiple); and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147099 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nf2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vestibular schwannomatosis	Alliance	Schwannomatosis, somatic	101000
vestibular schwannomatosis	Alliance	Schwannomatosis, vestibular	101000
		Meningioma, NF2-related, somatic	607174

Associated With nf2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
choledochal cyst	nf2b^hi3332Tg	standard conditions	Sadler et al., 2005

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR011259	Ezrin/radixin/moesin, C-terminal
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR041789	ERM family, FERM domain C-lobe
Domain	IPR046810	Ezrin/radixin/moesin, alpha-helical domain
Family	IPR000798	Ezrin/radixin/moesin-like
Family	IPR011174	Ezrin/radixin/moesin
Homologous_superfamily	IPR008954	Moesin tail domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	ERM family, FERM domain C-lobe	Ezrin/radixin/moesin	Ezrin/radixin/moesin, alpha-helical domain	Ezrin/radixin/moesin, C-terminal	Ezrin/radixin/moesin-like	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM, N-terminal	FERM superfamily, second domain	Moesin tail domain superfamily	PH-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:Q6Q413 InterPro	586

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	nf2b-203 (1) Ensembl	Ensembl	1,630 nt	Select Tool ZFIN BLAST
mRNA	nf2b-201 (1) Ensembl	Ensembl	2,154 nt	Select Tool ZFIN BLAST
mRNA	nf2b-202 (1) Ensembl	Ensembl	5,239 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations