Gene

psmb1

ID

ZDB-GENE-040618-2

Name

proteasome 20S subunit beta 1

Symbol

psmb1 Nomenclature History

Previous Names

proteasome beta-subunit C5 (1)
wu:fc51f06
zgc:103665

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have endopeptidase activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm; nucleus; and proteasome core complex. Orthologous to human PSMB1 (proteasome 20S subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	620038

Associated With psmb1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
microcephaly	TU + MO2-psmb1	standard conditions	Ansar et al., 2020
intellectual disability	TU + CRISPR3-psmb1	standard conditions	Ansar et al., 2020
intellectual disability	TU + MO1-psmb1	standard conditions	Ansar et al., 2020
intellectual disability	TU + CRISPR1-psmb1 + CRISPR2-psmb1	standard conditions	Ansar et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016050	Proteasome beta-type subunit, conserved site
Family	IPR001353	Proteasome, subunit alpha/beta
Family	IPR023333	Proteasome B-type subunit
Homologous_superfamily	IPR029055	Nucleophile aminohydrolases, N-terminal