Gene
tbpl2
- ID
- ZDB-GENE-040520-3
- Name
- TATA box binding protein like 2
- Symbol
- tbpl2 Nomenclature History
- Previous Names
-
- tbp2 (1)
- trf3
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in embryo development; embryonic pattern specification; and hemopoiesis. Acts upstream of or within DNA-templated transcription initiation. Predicted to be located in nucleus. Is expressed in margin. Orthologous to human TBPL2 (TATA-box binding protein like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23007 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tbpl2 | N/A | (2) |
| MO2-tbpl2 | N/A | Zhao et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TATA-box binding protein | TATA-box binding protein, conserved site | TATA-box binding protein, eukaryotic | TBP domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q1JPY4
|
312 | ||||
|
UniProtKB:A0A8M2BH15
|
313 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-132G21 | ZFIN Curated Data | |
| Contained in | BAC | CH73-272K2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136482 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191272 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214796 (1) | 1601 nt | ||
| Genomic | GenBank:CU467982 (2) | 114155 nt | ||
| Polypeptide | UniProtKB:A0A8M2BH15 (1) | 313 aa |
- Zhang, R., Tu, Y.X., Ye, D., Gu, Z., Chen, Z.X., Sun, Y. (2022) A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(36):e2203631
- Khuansuwan, S., Barnhill, L.M., Cheng, S., Bronstein, J.M. (2019) A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons. Autophagy. 15(8):1322-1332
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Zhao, X.X., Zhang, Y.B., Ni, P.L., Wu, Z.L., Yan, Y.C., Li, Y.P. (2016) Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. The Journal of biological chemistry. 291(1):402-12
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
- Hart, D.O., Santra, M.K., Raha, T., and Green, M.R. (2009) Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(10):2540-2549
- Hart, D.O., Raha, T., Lawson, N.D., and Green, M.R. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 450(7172):1082-1085
- Bartfai, R., Balduf, C., Hilton, T., Rathmann, Y., Hadzhiev, Y., Tora, L., Orbán, L., and Muller, F. (2004) TBP2, a Vertebrate-Specific Member of the TBP Family, Is Required in Embryonic Development of Zebrafish. Current biology : CB. 14(7):593-598
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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