Gene
hmgcl
- ID
- ZDB-GENE-040426-958
- Name
- 3-hydroxy-3-methylglutaryl-CoA lyase
- Symbol
- hmgcl Nomenclature History
- Previous Names
-
- zgc:56248
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA lyase deficiency | Alliance | HMG-CoA lyase deficiency | 246450 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | HMG-CoA lyase | Hydroxymethylglutaryl-CoA lyase, active site | Pyruvate carboxyltransferase |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZV32
|
340 |
Interactions and Pathways
No data available
Plasmids
No data available