Gene
ythdf2
- ID
- ZDB-GENE-040426-948
- Name
- YTH N6-methyladenosine RNA binding protein F2
- Symbol
- ythdf2 Nomenclature History
- Previous Names
-
- yth2
- zgc:56224
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables N6-methyladenosine-containing RNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; mRNA destabilization; and negative regulation of Notch signaling pathway. Acts upstream of or within hematopoietic stem cell proliferation and mRNA catabolic process. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytoplasm. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56224 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ch200 | Allele with one deletion | Unknown | Premature Stop | TALEN | |
| ihb685 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| ihb686 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| sa1176 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36430 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ya3322 | Allele with one deletion | Exon 4 | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | YTH domain | YTH domain containing protein |
|---|---|---|---|
|
UniProtKB:E7F1H9
|
613 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ythdf2-201
(1)
|
Ensembl | 3,021 nt | ||
| mRNA |
ythdf2-203
(1)
|
Ensembl | 2,394 nt | ||
| ncRNA |
ythdf2-002
(1)
|
Ensembl | 963 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-172J22 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-358O18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56224 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200250 (1) | 2131 nt | ||
| Genomic | GenBank:FP015965 (1) | 73800 nt | ||
| Polypeptide | UniProtKB:E7F1H9 (1) | 613 aa |
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Vopalensky, P., Pralow, S., Vastenhouw, N.L. (2018) Reduced expression of the Nodal coreceptor Oep causes loss of mesendodermal competence in zebrafish. Development (Cambridge, England). 145(5)
- Zhang, C., Chen, Y., Sun, B., Wang, L., Yang, Y., Ma, D., Lv, J., Heng, J., Ding, Y., Xue, Y., Lu, X., Xiao, W., Yang, Y.G., Liu, F. (2017) m6A modulates haematopoietic stem and progenitor cell specification.. Nature. 549(7671):273-276
- Zhao, B.S., Wang, X., Beadell, A.V., Lu, Z., Shi, H., Kuuspalu, A., Ho, R.K., He, C. (2017) m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.. Nature. 542(7642):475-478
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Manchenkov, T., Pasillas, M.P., Haddad, G.G., Imam, F.B. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 5(6):1107-16
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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