Gene

hdac3

ID

ZDB-GENE-040426-847

Name

histone deacetylase 3

Symbol

hdac3 Nomenclature History

Previous Names

zgc:55927 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have chromatin binding activity; histone deacetylase activity; and transcription corepressor activity. Involved in several processes, including angiogenesis; liver development; and posterior lateral line development. Predicted to localize to cytoplasm; histone deacetylase complex; and transcription repressor complex. Is expressed in several structures, including axial blood vessel; blood vessel; digestive system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55927 (1 image)
MGC:55927 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hdac3 Human Ortholog

No data available

Associated With hdac3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023801	Histone deacetylase domain
Family	IPR000286	Histone deacetylase family
Family	IPR003084	Histone deacetylase
Family	IPR050284	Histone deacetylase and polyamine deacetylase
Homologous_superfamily	IPR023696	Ureohydrolase domain superfamily
Homologous_superfamily	IPR037138	Histone deacetylase domain superfamily

Domain Details Per Protein

Protein	Length	Histone deacetylase	Histone deacetylase and polyamine deacetylase	Histone deacetylase domain	Histone deacetylase domain superfamily	Histone deacetylase family	Ureohydrolase domain superfamily
UniProtKB:Q803C3 InterPro	428

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hdac3-202 (1) Ensembl	Ensembl	705 nt	Select Tool
mRNA	hdac3-201 (1) Ensembl	Ensembl	2,138 nt	Select Tool
mRNA	ottdart00000032801 (1)	Havana	2,135 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations