Gene

prkcsh

ID

ZDB-GENE-040426-770

Name

PRKCSH beta subunit of glucosidase II

Symbol

prkcsh Nomenclature History

Previous Names

zgc:55653

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and kinase activity. Involved in liver development and pronephros development. Predicted to localize to endoplasmic reticulum. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55653 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkcsh Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
polycystic liver disease 1	Alliance	Polycystic liver disease 1	174050

Associated With prkcsh Via Experimental Models

Human Disease	Fish	Conditions	Citations
polycystic liver disease	WT + MO1-prkcsh	standard conditions	Tietz Bogert et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR028146	Glucosidase II beta subunit, N-terminal
Domain	IPR036607	Glucosidase 2 subunit beta-like
Domain	IPR044865	MRH domain
Family	IPR039794	Glucosidase II beta subunit-like
Homologous_superfamily	IPR009011	Mannose-6-phosphate receptor binding domain superfamily

Domain Details Per Protein

Protein	Length	EF-Hand 1, calcium-binding site	EF-hand domain	Glucosidase 2 subunit beta-like	Glucosidase II beta subunit-like	Glucosidase II beta subunit, N-terminal	Mannose-6-phosphate receptor binding domain superfamily	MRH domain
UniProtKB:Q802Z2 InterPro	529
UniProtKB:A0A8M2BBI5 InterPro	572

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkcsh-201 (1) Ensembl	Ensembl	2,118 nt	Select Tool
mRNA	prkcsh-202 (1) Ensembl	Ensembl	820 nt	Select Tool
mRNA	prkcsh-203 (1) Ensembl	Ensembl	759 nt	Select Tool
mRNA	prkcsh-204 (1) Ensembl	Ensembl	2,612 nt	Select Tool ZFIN BLAST
mRNA	prkcsh-205 (1) Ensembl	Ensembl	5,801 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations