Gene
msh2
- ID
- ZDB-GENE-040426-2932
- Name
- mutS homolog 2 (E. coli)
- Symbol
- msh2 Nomenclature History
- Previous Names
-
- wu:fc06b02
- wu:fc13e09
- zgc:55333
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Exhibits guanine/thymine mispair binding activity. Predicted to contribute to DNA binding activity and MutLalpha complex binding activity. Involved in maintenance of DNA repeat elements. Predicted to localize to MutSalpha complex and MutSbeta complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Is expressed in alar plate midbrain region; immature eye; nervous system; and pharyngeal arch 3-7 skeleton. Orthologous to human MSH2 (mutS homolog 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151921 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Feitsma et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lynch syndrome 1 | Alliance | Lynch syndrome 1 | 120435 |
| Muir-Torre syndrome | Alliance | Muir-Torre syndrome | 158320 |
| Mismatch repair cancer syndrome 2 | 619096 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Domain | IPR007860 | DNA mismatch repair protein MutS, connector domain |
| Domain | IPR007861 | DNA mismatch repair protein MutS, clamp |
| Domain | IPR032642 | DNA mismatch repair protein Msh2, ATP-binding cassette domain |
| Family | IPR011184 | DNA mismatch repair Msh2-type |
| Homologous_superfamily | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
| Homologous_superfamily | IPR036678 | MutS, connector domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair Msh2-type | DNA mismatch repair protein Msh2, ATP-binding cassette domain | DNA mismatch repair protein MutS, clamp | DNA mismatch repair protein MutS, connector domain | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | DNA mismatch repair protein MutS-like, N-terminal | DNA mismatch repair protein MutS, N-terminal | MutS, connector domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q803R6
|
936 |
Interactions and Pathways
No data available
Plasmids
No data available