Gene
chia.3
- ID
- ZDB-GENE-040426-2891
- Name
- chitinase, acidic.3
- Symbol
- chia.3 Nomenclature History
- Previous Names
-
- chia3 (1)
- wu:fd61a02
- wu:fi13f01
- zgc:55406
- zgc:77912
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in extracellular region. Is expressed in gut and intestinal bulb. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55406 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2585 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11781 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12464 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001579 | Glycosyl hydrolase family 18, active site |
| Domain | IPR001223 | Glycoside hydrolase family 18, catalytic domain |
| Domain | IPR002557 | Chitin binding domain |
| Family | IPR050314 | Glycosyl Hydrolase Family 18 |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Length | Chitinase insertion domain superfamily | Chitin binding domain | Chitin binding domain superfamily | Glycoside hydrolase family 18, catalytic domain | Glycoside hydrolase superfamily | Glycosyl Hydrolase Family 18 | Glycosyl hydrolase family 18, active site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZZ8
|
471 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chia.3-201
(1)
|
Ensembl | 1,737 nt | ||
| mRNA |
chia.3-202
(1)
|
Ensembl | 755 nt | ||
| mRNA |
chia.3-205
(1)
|
Ensembl | 1,922 nt | ||
| mRNA |
chia.3-206
(1)
|
Ensembl | 1,101 nt | ||
| ncRNA |
chia.3-003
(1)
|
Ensembl | 533 nt |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-169D4 | ZFIN Curated Data | |
| Encodes | EST | fd61a02 | ZFIN Curated Data | |
| Encodes | EST | fi13f01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55406 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77912 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191365 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213213 (1) | 1746 nt | ||
| Genomic | GenBank:CU571319 (1) | 99284 nt | ||
| Polypeptide | UniProtKB:Q6NZZ8 (1) | 471 aa |
No data available
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Lanes, C.F.C., Pedron, F.A., Bergamin, G.T., Bitencourt, A.L., Dorneles, B.E.R., Villanova, J.C.V., Dias, K.C., Riolo, K., Oliva, S., Savastano, D., Giannetto, A. (2021) Black Soldier Fly (Hermetia illucens) Larvae and Prepupae Defatted Meals in Diets for Zebrafish (Danio rerio). Animals : an open access journal from MDPI. 11(3):
- Zarantoniello, M., Randazzo, B., Cardinaletti, G., Truzzi, C., Chemello, G., Riolo, P., Olivotto, I. (2021) Possible Dietary Effects of Insect-Based Diets across Zebrafish (Danio rerio) Generations: A Multidisciplinary Study on the Larval Phase. Animals : an open access journal from MDPI. 11(3):
- Serikuly, N., Alpyshov, E.T., Wang, D., Wang, J., Yang, L., Hu, G., Yan, D., Demin, K.A., Kolesnikova, T.O., Galstyan, D., Amstislavskaya, T.G., Babashev, A.M., Mor, M.S., Efimova, E.V., Gainetdinov, R.R., Strekalova, T., de Abreu, M.S., Song, C., Kalueff, A.V. (2020) Effects of acute and chronic arecoline in adult zebrafish: Anxiolytic-like activity, elevated brain monoamines and the potential role of microglia. Progress in neuro-psychopharmacology & biological psychiatry. 104:109977
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Zarantoniello, M., Randazzo, B., Gioacchini, G., Truzzi, C., Giorgini, E., Riolo, P., Gioia, G., Bertolucci, C., Osimani, A., Cardinaletti, G., Lucon-Xiccato, T., Milanović, V., Annibaldi, A., Tulli, F., Notarstefano, V., Ruschioni, S., Clementi, F., Olivotto, I. (2020) Zebrafish (Danio rerio) physiological and behavioural responses to insect-based diets: a multidisciplinary approach. Scientific Reports. 10:10648
- Zhang, M.Q., Chen, B., Zhang, J.P., Chen, N., Liu, C.Z., Hu, C.Q. (2020) Liver toxicity of macrolide antibiotics in zebrafish. Toxicology. 441:152501
- Zarantoniello, M., Randazzo, B., Truzzi, C., Giorgini, E., Marcellucci, C., Vargas-Abúndez, J.A., Zimbelli, A., Annibaldi, A., Parisi, G., Tulli, F., Riolo, P., Olivotto, I. (2019) A six-months study on Black Soldier Fly (Hermetia illucens) based diets in zebrafish. Scientific Reports. 9:8598
- Vargas, A., Randazzo, B., Riolo, P., Truzzi, C., Gioacchini, G., Giorgini, E., Loreto, N., Ruschioni, S., Zarantoniello, M., Antonucci, M., Polverini, S., Cardinaletti, G., Sabbatini, S., Tulli, F., Olivotto, I. (2018) Rearing Zebrafish on Black Soldier Fly (Hermetia illucens): Biometric, Histological, Spectroscopic, Biochemical, and Molecular Implications. Zebrafish. 15(4):404-419
- Zarantoniello, M., Bruni, L., Randazzo, B., Vargas, A., Gioacchini, G., Truzzi, C., Annibaldi, A., Riolo, P., Parisi, G., Cardinaletti, G., Tulli, F., Olivotto, I. (2018) Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zebrafish. 15(5):519-532
1 - 10 of 15
Show