Gene
rab11ba
- ID
- ZDB-GENE-040426-2860
- Name
- RAB11B, member RAS oncogene family, a
- Symbol
- rab11ba Nomenclature History
- Previous Names
-
- rab11b
- wu:fb07g11
- zgc:55760 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in exocytosis. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in several structures, including caudal vein plexus; gut; nervous system; pectoral fin bud; and pronephric duct. Orthologous to human RAB11B (RAB11B, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144609 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hao et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zju234 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | 617807 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Rab GTPases family involved in membrane trafficking | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q802D1
|
218 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab11ba-201
(1)
|
Ensembl | 1,804 nt | ||
| mRNA |
rab11ba-202
(1)
|
Ensembl | 788 nt | ||
| ncRNA |
rab11ba-003
(1)
|
Ensembl | 726 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:GFP-rab11ba_S25N) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197G15 | ZFIN Curated Data | |
| Encodes | EST | fb07g11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144609 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55760 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192216 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214770 (1) | 1814 nt | ||
| Genomic | GenBank:BX649327 (1) | 206348 nt | ||
| Polypeptide | UniProtKB:Q802D1 (1) | 218 aa |
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Hao, Y., Zhou, Y., Yu, Y., Zheng, M., Weng, K., Kou, Z., Liang, J., Zhang, Q., Tang, X., Xu, P., Link, B.A., Yao, K., Zou, J. (2020) Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. Development (Cambridge, England). 147(22):
- Zhang, H., Gao, Y., Qian, P., Dong, Z., Hao, W., Liu, D., Duan, X. (2019) Expression analysis of Rab11 during zebrafish embryonic development. BMC Developmental Biology. 19:25
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hall, T.E., Martel, N., Lo, H.P., Xiong, Z., Parton, R.G. (2017) A plasmid library of full-length zebrafish rab proteins for in vivo cell biology.. Cellular logistics. 7:e1301151
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Alvers, A.L., Ryan, S., Scherz, P.J., Huisken, J., and Bagnat, M. (2014) Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development (Cambridge, England). 141(5):1110-1119
- Clark, B.S., Winter, M., Cohen, A.R., and Link, B.A. (2011) Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(11):2452-2465
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