Gene
arhgdia
- ID
- ZDB-GENE-040426-2816
- Name
- Rho GDP dissociation inhibitor (GDI) alpha
- Symbol
- arhgdia Nomenclature History
- Previous Names
-
- wu:fa96g11
- zgc:55554 (1)
- zgc:77681
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable Rho GDP-dissociation inhibitor activity. Acts upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and membrane. Is expressed in retinal ganglion cell layer. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55554 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gee et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010428Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015287Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028959Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 8 | Alliance | Nephrotic syndrome, type 8 | 615244 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nephrotic syndrome | AB + MO1-arhgdia + MO4-tp53 | standard conditions | Gee et al., 2013 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Rho GDP-dissociation inhibitor domain superfamily | Rho protein GDP-dissociation inhibitor |
|---|---|---|---|---|
|
UniProtKB:Q802W6
|
203 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgdia-201
(1)
|
Ensembl | 2,196 nt | ||
| mRNA |
arhgdia-202
(1)
|
Ensembl | 855 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-43F19 | ZFIN Curated Data | |
| Encodes | EST | fa96g11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55554 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77681 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191202 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213461 (1) | 2213 nt | ||
| Genomic | GenBank:CU693479 (2) | 145296 nt | ||
| Polypeptide | UniProtKB:Q802W6 (1) | 203 aa |
- Jean, F., Pilgrim, D. (2019) Evolution and expression of the zebrafish unc119 paralogues indicates a conserved role in cilia. Gene expression patterns : GEP. 33:1-10
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shen, K., Sidik, H., Talbot, W.S. (2016) The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Cell Reports. 14(3):547-59
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Gee, H.Y., Saisawat, P., Ashraf, S., Hurd, T.W., Vega-Warner, V., Fang, H., Beck, B.B., Gribouval, O., Zhou, W., Diaz, K.A., Natarajan, S., Wiggins, R.C., Lovric, S., Chernin, G., Schoeb, D.S., Ovunc, B., Frishberg, Y., Soliman, N.A., Fathy, H.M., Goebel, H., Hoefele, J., Weber, L.T., Innis, J.W., Faul, C., Han, Z., Washburn, J., Antignac, C., Levy, S., Otto, E.A., and Hildebrandt, F. (2013) ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. J. Clin. Invest.. 123(8):3243-3253
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Veldman, M.B., Bemben, M.A., Thompson, R.C., and Goldman, D. (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. 312(2):596-612
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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