Gene
pgd
- ID
- ZDB-GENE-040426-2807
- Name
- phosphogluconate dehydrogenase
- Symbol
- pgd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable NADP binding activity and phosphogluconate dehydrogenase (decarboxylating) activity. Predicted to be involved in D-gluconate catabolic process and pentose-phosphate shunt, oxidative branch. Predicted to act upstream of or within D-gluconate metabolic process and pentose-phosphate shunt. Predicted to be active in cytosol. Is expressed in several structures, including axis; chordo neural hinge; digestive system; sensory system; and solid lens vesicle. Orthologous to human PGD (phosphogluconate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55585 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR006184 | 6-phosphogluconate-binding site |
| Domain | IPR006114 | 6-phosphogluconate dehydrogenase, C-terminal |
| Domain | IPR006115 | 6-phosphogluconate dehydrogenase, NADP-binding |
| Family | IPR006113 | 6-phosphogluconate dehydrogenase, decarboxylating |
| Family | IPR006183 | 6-phosphogluconate dehydrogenase |
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Domain Details Per Protein
| Protein | Length | 6-phosphogluconate-binding site | 6-phosphogluconate dehydrogenase | 6-phosphogluconate dehydrogenase, C-terminal | 6-phosphogluconate dehydrogenase, decarboxylating | 6-phosphogluconate dehydrogenase, domain 2 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | 6-phosphogluconate dehydrogenase, NADP-binding | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q883
|
511 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-129O18 | ZFIN Curated Data | |
| Encodes | EST | fi03d03 | ||
| Encodes | cDNA | MGC:55585 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111848 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192843 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213453 (1) | 1894 nt | ||
| Genomic | GenBank:BX957303 (1) | 110532 nt | ||
| Polypeptide | UniProtKB:F1Q883 (1) | 511 aa |
- Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140
- Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:
- Huang, Y., Yu, S.H., Zhen, W.X., Cheng, T., Wang, D., Lin, J.B., Wu, Y.H., Wang, Y.F., Chen, Y., Shu, L.P., Wang, Y., Sun, X.J., Zhou, Y., Yang, F., Hsu, C.H., Xu, P.F. (2021) Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 11:6891-6904
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Delaney, P., Ramdas Nair, A., Palmer, C., Khan, N., Sadler, K.C. (2020) Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish. Toxicology and applied pharmacology. 409:115307
- Kwok, M.L., Hu, X.L., Meng, Q., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) analyses of the zebrafish liver cell line, ZFL, after acute exposure to Cu2+ ions. Metallomics : integrated biometal science. 12(5):732-751
- Kwok, M.L., Meng, Q., Hu, X.L., Chung, C.T., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) study of the ZFL zebrafish liver cell line after acute exposure to Cd2+ ions. Aquatic toxicology (Amsterdam, Netherlands). 228:105628
- Jia, J., Qin, J., Yuan, X., Liao, Z., Huang, J., Wang, B., Sun, C., Li, W. (2019) Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio). BMC Genomics. 20:919
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