Gene
eif4a2
- ID
- ZDB-GENE-040426-2802
- Name
- eukaryotic translation initiation factor 4A2
- Symbol
- eif4a2 Nomenclature History
- Previous Names
-
- wu:fd50g11
- zgc:63783 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translational initiation. Is expressed in several structures, including alar plate midbrain region; head; immature eye; midbrain; and segmental plate. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6906198 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with hypotonia and speech delay | Alliance | Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures | 620455 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
| Domain | IPR044728 | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent RNA helicase DEAD-box, conserved site | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SXU5
|
280 | |||||||
|
UniProtKB:F1R166
|
411 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
eif4a2-202
(1)
|
Ensembl | 868 nt | ||
| mRNA |
eif4a2-201
(1)
|
Ensembl | 1,825 nt |
Interactions and Pathways
No data available
Plasmids
No data available