Gene

e2f4

ID

ZDB-GENE-040426-2773

Name

E2F transcription factor 4

Symbol

e2f4 Nomenclature History

Previous Names

fb72f07
wu:fb72f07 (1)
wu:fe05f06
zgc:63815

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Predicted to localize to RNA polymerase II transcription factor complex. Is expressed in adenohypophysis; head; and trunk. Orthologous to human E2F4 (E2F transcription factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63815 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Xie et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With e2f4 Human Ortholog

No data available

Associated With e2f4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Domain	IPR032198	E2F transcription factor, CC-MB domain
Family	IPR015633	E2F Family
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR037241	E2F-DP heterodimerization region