Gene
pfkfb3
- ID
- ZDB-GENE-040426-2724
- Name
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
- Symbol
- pfkfb3 Nomenclature History
- Previous Names
-
- zgc:73257
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Is expressed in Purkinje cell. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11437 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001345 | Phosphoglycerate/bisphosphoglycerate mutase, active site |
| Domain | IPR013079 | 6-phosphofructo-2-kinase |
| Family | IPR003094 | Fructose-2,6-bisphosphatase |
| Family | IPR013078 | Histidine phosphatase superfamily, clade-1 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Length | 6-phosphofructo-2-kinase | Fructose-2,6-bisphosphatase | Histidine phosphatase superfamily | Histidine phosphatase superfamily, clade-1 | Phosphoglycerate/bisphosphoglycerate mutase, active site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IBD1
|
527 | ||||||
|
UniProtKB:A0A8M2BC55
|
519 | ||||||
|
UniProtKB:A0A8M9PH83
|
296 | ||||||
|
UniProtKB:Q6P951
|
536 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pfkfb3-201
(1)
|
Ensembl | 3,328 nt | ||
| mRNA |
pfkfb3-205
(1)
|
Ensembl | 3,525 nt | ||
| ncRNA |
pfkfb3-002
(1)
|
Ensembl | 789 nt | ||
| ncRNA |
pfkfb3-003
(1)
|
Ensembl | 724 nt | ||
| ncRNA |
pfkfb3-004
(1)
|
Ensembl | 464 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284L9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73257 | ZFIN Curated Data | |
| Has Artifact | EST | fc31e01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213397 (1) | 3326 nt | ||
| Genomic | GenBank:BX842686 (1) | 71843 nt | ||
| Polypeptide | UniProtKB:Q6P951 (1) | 536 aa |
- Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589
- Lee, Y., Park, J., Kim, S.M., Nam, K., Lee, W., Cho, H., Han, I.O. (2020) Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:853-864
- Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
- Ratnayake, R., Gunasekera, S.P., Ma, J.J., Dang, L.H., Carney, T., Paul, V.J., Luesch, H. (2020) Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. Chembiochem : a European journal of chemical biology. 21(16):2356-2366
- Mehjabin, R., Chen, L., Huang, R., Zhu, D., Yang, C., Li, Y., Liao, L., He, L., Zhu, Z., Wang, Y. (2019) Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Fish & shellfish immunology. 87:788-795
- Xu, S., Wang, G., Peng, W., Xu, Y., Zhang, Y., Ge, Y., Jing, Y., Gong, Z. (2019) Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats. Scientific Reports. 9:4388
- Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M.M., Marín-Juez, R., Guenther, S., Maischein, H.M., Fukuda, N., Canham, M.A., Brickman, J.M., Bogue, C.W., Jayaraman, P.S., Stainier, D.Y.R. (2018) HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature communications. 9:2704
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