Gene

pfkfb3

ID

ZDB-GENE-040426-2724

Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Symbol

pfkfb3 Nomenclature History

Previous Names

zgc:73257

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Is expressed in Purkinje cell. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfkfb3 Human Ortholog

No data available

Associated With pfkfb3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain	IPR013079	6-phosphofructo-2-kinase
Family	IPR003094	Fructose-2,6-bisphosphatase
Family	IPR013078	Histidine phosphatase superfamily, clade-1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029033	Histidine phosphatase superfamily

Domain Details Per Protein

Protein	Length	6-phosphofructo-2-kinase	Fructose-2,6-bisphosphatase	Histidine phosphatase superfamily	Histidine phosphatase superfamily, clade-1	Phosphoglycerate/bisphosphoglycerate mutase, active site	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A0R4IBD1 InterPro	527
UniProtKB:A0A8M2BC55 InterPro	519
UniProtKB:A0A8M9PH83 InterPro	296
UniProtKB:Q6P951 InterPro	536

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pfkfb3-201 (1) Ensembl	Ensembl	3,328 nt	Select Tool ZFIN BLAST
mRNA	pfkfb3-205 (1) Ensembl	Ensembl	3,525 nt	Select Tool ZFIN BLAST
ncRNA	pfkfb3-002 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST
ncRNA	pfkfb3-003 (1) Ensembl	Ensembl	724 nt	Select Tool ZFIN BLAST
ncRNA	pfkfb3-004 (1) Ensembl	Ensembl	464 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations