Gene
gab1
- ID
- ZDB-GENE-040426-2674
- Name
- GRB2-associated binding protein 1
- Symbol
- gab1 Nomenclature History
- Previous Names
-
- fb11b01
- fc66d01
- wu:fb11b01
- wu:fc66d01
- zgc:56412 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity. Acts upstream of or within epiboly. Predicted to be active in cytoplasm. Is expressed in brain and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56412 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Yousaf et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 26 | Alliance | ?Deafness, autosomal recessive 26 | 605428 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GRB2-associated-binding protein 1-4-like | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|
|
UniProtKB:A0A8M9P5A1
|
754 | |||
|
UniProtKB:A0A8M6YVD8
|
742 | |||
|
UniProtKB:A0A8M6YUV9
|
770 | |||
|
UniProtKB:A0A8M9PTD5
|
726 | |||
|
UniProtKB:A0A8M9PWZ6
|
667 | |||
|
UniProtKB:F1Q7S5
|
740 | |||
|
UniProtKB:F6NTT0
|
712 |
Interactions and Pathways
No data available
Plasmids
No data available