Gene

ak4

ID

ZDB-GENE-040426-2505

Name

adenylate kinase 4

Symbol

ak4 Nomenclature History

Previous Names

ak3l1
wu:fc37g02
zgc:85790

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have nucleobase-containing compound kinase activity and purine ribonucleoside triphosphate binding activity. Predicted to be involved in ATP metabolic process; phosphorylation; and purine ribonucleotide metabolic process. Predicted to localize to mitochondrial matrix. Is expressed in axis; nervous system; neural tube; pronephric duct; and somite. Orthologous to human AK4 (adenylate kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85790 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ak4 Human Ortholog

No data available

Associated With ak4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR033690	Adenylate kinase, conserved site
Domain	IPR007862	Adenylate kinase, active site lid domain
Family	IPR000850	Adenylate kinase/UMP-CMP kinase
Family	IPR006259	Adenylate kinase subfamily
Family	IPR028585	Adenylate kinase 4, mitochondrial
Family	IPR028586	Adenylate kinase 3/4, mitochondrial
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036193	Adenylate kinase, active site lid domain superfamily

Domain Details Per Protein

Protein	Length	Adenylate kinase 3/4, mitochondrial	Adenylate kinase 4, mitochondrial	Adenylate kinase, active site lid domain	Adenylate kinase, active site lid domain superfamily	Adenylate kinase, conserved site	Adenylate kinase subfamily	Adenylate kinase/UMP-CMP kinase	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6NUY0 InterPro	226

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ak4-201 (1) Ensembl	Ensembl	2,213 nt	Select Tool ZFIN BLAST
mRNA	ak4-202 (1) Ensembl	Ensembl	1,015 nt	Select Tool
mRNA	ak4-203 (1) Ensembl	Ensembl	2,373 nt	Select Tool
mRNA	ak4-204 (1) Ensembl	Ensembl	4,195 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations