Gene

mccc2

ID

ZDB-GENE-040426-2493

Name

methylcrotonyl-CoA carboxylase subunit 2

Symbol

mccc2 Nomenclature History

Previous Names

si:dkey-57m14.1 (1)
zgc:85685

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Predicted to localize to methylcrotonoyl-CoA carboxylase complex and mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonoyl-CoA carboxylase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85685 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mccc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
3-methylcrotonyl-CoA carboxylase 2 deficiency	Alliance	3-Methylcrotonyl-CoA carboxylase 2 deficiency	210210

Associated With mccc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Family	IPR045190	Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
Homologous_superfamily	IPR029045	ClpP/crotonase-like domain superfamily