Gene

arih2

ID

ZDB-GENE-040426-2158

Name

ariadne homolog 2 (Drosophila)

Symbol

arih2 Nomenclature History

Previous Names

wu:fa09c12
zgc:64093

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64093 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arih2 Human Ortholog

No data available

Associated With arih2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR002867	IBR domain
Domain	IPR044066	TRIAD supradomain
Domain	IPR045840	Ariadne domain
Domain	IPR047555	E3 ubiquitin-protein ligase ARIH2, BRcat domain
Domain	IPR047556	E3 ubiquitin-protein ligase TRIAD1, Rcat domain
Family	IPR031127	E3 ubiquitin ligase RBR family
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type