Gene
pgrmc2
- ID
- ZDB-GENE-040426-2102
- Name
- progesterone receptor membrane component 2
- Symbol
- pgrmc2 Nomenclature History
- Previous Names
-
- wu:fb25g12
- wu:fd12f11
- zgc:56692
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within oocyte maturation and ovulation. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; gonad; heart; integument; and muscle. Orthologous to human PGRMC2 (progesterone receptor membrane component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56692 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecu10 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la020030Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain superfamily |
|---|---|---|---|
|
UniProtKB:Q7SZC7
|
201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pgrmc2-201
(1)
|
Ensembl | 2,389 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-221L4 | ZFIN Curated Data | |
| Encodes | EST | fb25g12 | ||
| Encodes | EST | fd12f11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56692 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213104 (1) | 2353 nt | ||
| Genomic | GenBank:AL928908 (1) | 229790 nt | ||
| Polypeptide | UniProtKB:Q7SZC7 (1) | 201 aa |
- Ramachandran, D., Sharma, K., Saxena, V., Nipu, N., Rajapaksha, D.C., Mennigen, J.A. (2023) Knock-out of vasotocin reduces reproductive success in female zebrafish, Danio rerio. Frontiers in endocrinology. 14:11512991151299
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Wu, X.J., Jermaul Williams, M., Rameshkumar Patel, P., Ann Kew, K., Zhu, Y. (2019) Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish. General and comparative endocrinology. 282:113218
- Wu, X.J., Zhu, Y. (2019) Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish. General and comparative endocrinology. 285:113275
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- van der Ven, K., Keil, D., Moens, L.N., Van Leemput, K., van Remortel, P., and De Coen, W.M. (2006) Neuropharmaceuticals in the environment: mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays. Environmental toxicology and chemistry. 25(10):2645-2652
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