Gene
grb2b
- ID
- ZDB-GENE-040426-1975
- Name
- growth factor receptor-bound protein 2b
- Symbol
- grb2b Nomenclature History
- Previous Names
-
- grb2
- fb18e12
- wu:fb18e12
- wu:fb34e06
- zgc:73077
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in Golgi apparatus; endosome; and nucleus. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73077 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Mauri et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR035641 | GRB2, N-terminal SH3 domain |
| Domain | IPR035643 | GRB2, C-terminal SH3 domain |
| Family | IPR043539 | Grb2-like |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | GRB2, C-terminal SH3 domain | Grb2-like | GRB2, N-terminal SH3 domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PC73
|
217 |
Interactions and Pathways
No data available
Plasmids
No data available