Gene

dnaaf4

ID
ZDB-GENE-040426-1892
Name
dynein axonemal assembly factor 4
Symbol
dnaaf4 Nomenclature History
Previous Names
  • dyx1c1
  • zgc:77853
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have estrogen receptor binding activity. Involved in cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; and left/right axis specification. Predicted to localize to centrosome and non-motile cilium. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnaaf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ciliary dyskinesia 25 Alliance Ciliary dyskinesia, primary, 25 615482
{Dyslexia, susceptibility to, 1} 127700
Associated With dnaaf4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007052 CS domain
Domain IPR037894 Dynein axonemal assembly factor 4, CS domain
Family IPR052004 Axonemal Dynein Assembly Factor 4
Homologous_superfamily IPR008978 HSP20-like chaperone
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length Axonemal Dynein Assembly Factor 4 CS domain Dynein axonemal assembly factor 4, CS domain HSP20-like chaperone Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat
UniProtKB:Q6P010 420
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations