Gene

gne

ID

ZDB-GENE-040426-1848

Name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Symbol

gne Nomenclature History

Previous Names

zgc:77657 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits UDP-N-acetylglucosamine 2-epimerase activity. Involved in chordate embryonic development; locomotion; and muscle fiber development. Human ortholog(s) of this gene implicated in sialuria. Is expressed in digestive system; muscle; nervous system; and somite border. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Daya et al., 2014

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gne Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
GNE myopathy	Alliance	Nonaka myopathy	605820
sialuria	Alliance	Sialuria	269921
		Thrombocytopenia 12 with or without myopathy	620757

Associated With gne Via Experimental Models

Human Disease	Fish	Conditions	Citations
GNE myopathy	gne^rm4/rm4	standard conditions	Livne et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003331	UDP-N-acetylglucosamine 2-epimerase domain
Family	IPR000600	ROK family
Family	IPR020004	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain

Domain Details Per Protein

Protein	Length	ATPase, nucleotide binding domain	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	ROK family	UDP-N-acetylglucosamine 2-epimerase domain
UniProtKB:Q6P3K2 InterPro	725

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gne-201 (1) Ensembl	Ensembl	3,669 nt	Select Tool
mRNA	gne-202 (1) Ensembl	Ensembl	2,247 nt	Select Tool ZFIN BLAST
mRNA	gne-203 (1) Ensembl	Ensembl	801 nt	Select Tool
ncRNA	gne-003 (1) Ensembl	Ensembl	857 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations