Gene

scp2a

ID

ZDB-GENE-040426-1846

Name

sterol carrier protein 2a

Symbol

scp2a Nomenclature History

Previous Names

scp2
zgc:77634

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable lipid binding activity; propanoyl-CoA C-acyltransferase activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to be involved in positive regulation of intracellular cholesterol transport. Predicted to act upstream of or within lipid transport. Predicted to be located in mitochondrion and peroxisome. Is expressed in intestinal bulb; lens; liver; and solid lens vesicle. Orthologous to human SCP2 (sterol carrier protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77634 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scp2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Leukoencephalopathy with dystonia and motor neuropathy	613724

Associated With scp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020615	Thiolase, acyl-enzyme intermediate active site
Conserved_site	IPR020613	Thiolase, conserved site
Domain	IPR003033	SCP2 sterol-binding domain
Domain	IPR020616	Thiolase, N-terminal
Homologous_superfamily	IPR016039	Thiolase-like
Homologous_superfamily	IPR036527	SCP2 sterol-binding domain superfamily