Gene
bace1
- ID
- ZDB-GENE-040426-1835
- Name
- beta-secretase 1
- Symbol
- bace1 Nomenclature History
- Previous Names
-
- zgc:77409
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have aspartic-type endopeptidase activity. Involved in myelination in peripheral nervous system and positive regulation of myelination. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in brain. Orthologous to human BACE1 (beta-secretase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from van Bebber et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR033121 | Peptidase family A1 domain |
| Domain | IPR033874 | Memapsin-like |
| Family | IPR001461 | Aspartic peptidase A1 |
| Family | IPR009119 | Beta-secretase BACE |
| Family | IPR009120 | Beta-secretase BACE1 |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Beta-secretase BACE | Beta-secretase BACE1 | Memapsin-like | Peptidase family A1 domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZT7
|
505 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available