Gene
cfl2
- ID
- ZDB-GENE-040426-1815
- Name
- cofilin 2 (muscle)
- Symbol
- cfl2 Nomenclature History
- Previous Names
-
- zgc:77288
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to act upstream of or within actin filament depolymerization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in lens; myotome; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909063 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nemaline myopathy 7 | Alliance | Nemaline myopathy 7, autosomal recessive | 610687 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Actin-depolymerising factor homology domain | ADF/Cofilin | ADF-H/Gelsolin-like domain superfamily |
|---|---|---|---|---|
|
UniProtKB:Q6NZW3
|
166 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-32G17 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909063 | Thisse et al., 2004 | |
| Encodes | EST | fc42e05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77288 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205700 (1) | 2820 nt | ||
| Genomic | GenBank:CU928207 (2) | 47906 nt | ||
| Polypeptide | UniProtKB:Q6NZW3 (1) | 166 aa |
- Jin, S., Jeon, H., Choe, C.P. (2022) Expression and Functional Analysis of cofilin1-like in Craniofacial Development in Zebrafish. Development & reproduction. 26:23-36
- Fukuda, R., Gunawan, F., Ramadass, R., Beisaw, A., Konzer, A., Mullapudi, S.T., Gentile, A., Maischein, H.M., Graumann, J., Stainier, D.Y.R. (2019) Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis. Developmental Cell. 51(1):62-77.e5
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Zhang, Q., Ji, C., Ren, J., Zhang, Q., Dong, X., Zu, Y., Jia, L., Li, W. (2018) Differential transcriptome analysis of zebrafish (Danio rerio) larvae challenged by Vibrio parahaemolyticus. Journal of fish diseases. 41(7):1049-1062
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gunning, P.W., Ghoshdastider, U., Whitaker, S., Popp, D., Robinson, R.C. (2015) The evolution of compositionally and functionally distinct actin filaments. Journal of Cell Science. 128:2009-19
- Lin, C.W., Yen, S.T., Chang, H.T., Chen, S.J., Lai, S.L., Liu, Y.C., Chan, T.H., Liao, W.L., and Lee, S.J. (2010) Loss of Cofilin 1 Disturbs Actin Dynamics, Adhesion between Enveloping and Deep Cell Layers and Cell Movements during Gastrulation in Zebrafish. PLoS One. 5(12):e15331
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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