Gene

cfl2

ID

ZDB-GENE-040426-1815

Name

cofilin 2 (muscle)

Symbol

cfl2 Nomenclature History

Previous Names

zgc:77288

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to act upstream of or within actin filament depolymerization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in lens; myotome; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909063 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cfl2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nemaline myopathy 7	Alliance	Nemaline myopathy 7, autosomal recessive	610687

Associated With cfl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002108	Actin-depolymerising factor homology domain
Family	IPR017904	ADF/Cofilin
Homologous_superfamily	IPR029006	ADF-H/Gelsolin-like domain superfamily