Gene
xrcc4
- ID
- ZDB-GENE-040426-1755
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 4
- Symbol
- xrcc4 Nomenclature History
- Previous Names
-
- zgc:73312 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity. Predicted to be involved in DNA metabolic process; positive regulation of ligase activity; and response to X-ray. Predicted to localize to DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73312 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Short stature, microcephaly, and endocrine dysfunction | 616541 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR053961 | XRCC4, N-terminal domain |
Domain | IPR053962 | XRCC4, coiled-coil domain |
Domain | IPR053963 | XRCC4, C-terminal domain |
Family | IPR010585 | DNA repair protein XRCC4 |
Homologous_superfamily | IPR009089 | XRCC4, N-terminal domain superfamily |
Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
Homologous_superfamily | IPR038051 | XRCC4-like, N-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | DNA repair protein XRCC4 | DNA repair protein XRCC4-like, C-terminal | XRCC4, coiled-coil domain | XRCC4, C-terminal domain | XRCC4-like, N-terminal domain superfamily | XRCC4, N-terminal domain | XRCC4, N-terminal domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PBP2
|
357 | |||||||
UniProtKB:A0A2R8RHK7
|
358 |
Interactions and Pathways
No data available
Plasmids
No data available