Gene

xrcc4

ID
ZDB-GENE-040426-1755
Name
X-ray repair complementing defective repair in Chinese hamster cells 4
Symbol
xrcc4 Nomenclature History
Previous Names
  • zgc:73312 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have DNA binding activity. Predicted to be involved in DNA metabolic process; positive regulation of ligase activity; and response to X-ray. Predicted to localize to DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With xrcc4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Short stature, microcephaly, and endocrine dysfunction 616541
Associated With xrcc4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR053961 XRCC4, N-terminal domain
Domain IPR053962 XRCC4, coiled-coil domain
Domain IPR053963 XRCC4, C-terminal domain
Family IPR010585 DNA repair protein XRCC4
Homologous_superfamily IPR009089 XRCC4, N-terminal domain superfamily
Homologous_superfamily IPR014751 DNA repair protein XRCC4-like, C-terminal
Homologous_superfamily IPR038051 XRCC4-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length DNA repair protein XRCC4 DNA repair protein XRCC4-like, C-terminal XRCC4, coiled-coil domain XRCC4, C-terminal domain XRCC4-like, N-terminal domain superfamily XRCC4, N-terminal domain XRCC4, N-terminal domain superfamily
UniProtKB:Q6PBP2 357
UniProtKB:A0A2R8RHK7 358
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA xrcc4-201 (1) Ensembl 1,370 nt
mRNA xrcc4-202 (1) Ensembl 1,641 nt
mRNA xrcc4-203 (1) Ensembl 1,812 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations