Gene
wars1
- ID
- ZDB-GENE-040426-1742
- Name
- tryptophanyl-tRNA synthetase 1
- Symbol
- wars1 Nomenclature History
- Previous Names
-
- wars
- TrpRS (1)
- zgc:73274
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to have ATP binding activity and tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Is expressed in adaxial cell and myotome. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73274 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lin et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 9 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 9 | 617721 |
| Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities | 620317 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR000738 | WHEP-TRS domain |
| Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
| Family | IPR002306 | Tryptophan-tRNA ligase |
| Homologous_superfamily | IPR009068 | uS15/NS1, RNA-binding domain superfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ic | Aminoacyl-tRNA synthetase, class I, conserved site | Rossmann-like alpha/beta/alpha sandwich fold | Tryptophan-tRNA ligase | uS15/NS1, RNA-binding domain superfamily | WHEP-TRS domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PBS3
|
463 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available