Gene
wars1
- ID
- ZDB-GENE-040426-1742
- Name
- tryptophanyl-tRNA synthetase 1
- Symbol
- wars1 Nomenclature History
- Previous Names
-
- wars
- TrpRS (1)
- zgc:73274
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to enable ATP binding activity and tryptophan-tRNA ligase activity. Predicted to act upstream of or within tryptophanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Is expressed in adaxial cell and myotome. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73274 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lin et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 9 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 9 | 617721 |
| Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities | 620317 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR000738 | WHEP-TRS domain |
| Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
| Family | IPR002306 | Tryptophan-tRNA ligase |
| Homologous_superfamily | IPR009068 | uS15/NS1, RNA-binding domain superfamily |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ic | Aminoacyl-tRNA synthetase, class I, conserved site | Rossmann-like alpha/beta/alpha sandwich fold | Tryptophan-tRNA ligase | uS15/NS1, RNA-binding domain superfamily | WHEP-TRS domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PBS3
|
463 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available