Gene

rims2a

ID

ZDB-GENE-040426-1656

Name

regulating synaptic membrane exocytosis 2a

Symbol

rims2a Nomenclature History

Previous Names

rims2
zgc:73064

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have Rab GTPase binding activity and ion channel binding activity. Predicted to be involved in calcium ion-regulated exocytosis of neurotransmitter; modulation of chemical synaptic transmission; and regulation of membrane potential. Predicted to localize to cytoskeleton of presynaptic active zone and presynaptic membrane. Is expressed in nervous system and pancreatic system. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73064 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rims2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cone-rod synaptic disorder syndrome, congenital nonprogressive	618970

Associated With rims2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR001478	PDZ domain
Domain	IPR010911	Rab-binding domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR041489	PDZ domain 6
Domain	IPR054386	RIM, zinc finger
Family	IPR039032	Rim-like
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PDZ domain	PDZ domain 6	PDZ superfamily	Rab-binding domain	Rim-like	RIM, zinc finger	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M9NZV4 InterPro	1473
UniProtKB:A0A8M6YTP4 InterPro	1347
UniProtKB:A0A8M9PDV7 InterPro	308
UniProtKB:A0A8M9PNB2 InterPro	286
UniProtKB:A0A8M9P8J7 InterPro	313
UniProtKB:A0A8M9PKA5 InterPro	1397
UniProtKB:A0A8M3AIH2 InterPro	1512