Gene

upf3b

ID

ZDB-GENE-040426-1630

Name

UPF3B regulator of nonsense mediated mRNA decay

Symbol

upf3b Nomenclature History

Previous Names

zgc:174674
zgc:66390

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of translation. Predicted to localize to cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability and syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66390 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ma et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With upf3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked intellectual disability 14	Alliance	Intellectual developmental disorder, X-linked syndromic 14	300676

Associated With upf3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005120	UPF3 domain
Domain	IPR034979	UPF3B, RNA recognition motif-like domain
Family	IPR039722	Nonsense-mediated mRNA decay protein 3
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily