Gene

ctss1

ID

ZDB-GENE-040426-1583

Name

cathepsin S, ortholog 1

Symbol

ctss1 Nomenclature History

Previous Names

ctssa (1)
zgc:66267

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy and pycnodysostosis. Orthologous to human CTSK (cathepsin K) and CTSS (cathepsin S).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66267 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctss1 Human Ortholog

No data available

Associated With ctss1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR013201	Cathepsin propeptide inhibitor domain (I29)
Domain	IPR039417	Papain-like cysteine endopeptidase
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily