Gene
acsl4a
- ID
- ZDB-GENE-040426-1565
- Name
- acyl-CoA synthetase long chain family member 4a
- Symbol
- acsl4a Nomenclature History
- Previous Names
-
- acsl4
- acsl4b
- zgc:66186 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have catalytic activity. Involved in dorsal/ventral pattern formation and regulation of signal transduction. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66186 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Miyares et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 63 | Alliance | Intellectual developmental disorder, X-linked 63 | 300387 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AMP-binding | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6PFP1
|
706 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl4a-201
(1)
|
Ensembl | 3,852 nt | ||
| mRNA |
acsl4a-202
(1)
|
Ensembl | 2,154 nt |
Interactions and Pathways
No data available
Plasmids
No data available