Gene
cyba
- ID
- ZDB-GENE-040426-1526
- Name
- cytochrome b-245, alpha polypeptide
- Symbol
- cyba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have heme binding activity; metal ion binding activity; and oxidoreductase activity. Involved in macrophage chemotaxis and neutrophil migration. Predicted to localize to NADPH oxidase complex. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66077 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Schoen et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive chronic granulomatous disease 4 | Alliance | Chronic granulomatous disease 4, autosomal recessive | 233690 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Schoen et al., 2019 |
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Bastos et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007732 | Cytochrome b558 alpha-subunit |
Domain Details Per Protein
| Protein | Length | Cytochrome b558 alpha-subunit |
|---|---|---|
|
UniProtKB:Q6PH62
|
185 |
Interactions and Pathways
No data available
Plasmids
No data available