Gene
abcc2
- ID
- ZDB-GENE-040426-1523
- Name
- ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Symbol
- abcc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2688 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6282 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11900 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19049 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22191 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3512 | Allele with one delins | Exon 8 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dubin-Johnson syndrome | Alliance | Dubin-Johnson syndrome | 237500 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR005292 | Multi drug resistance-associated protein |
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Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | Multi drug resistance-associated protein | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1DB26
|
1567 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-250O1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-58O21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66072 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200589 (1) | 4925 nt | ||
| Genomic | GenBank:CR354539 (1) | 145294 nt | ||
| Polypeptide | UniProtKB:F1DB26 (1) | 1567 aa |
- Gao, S.Y., Zhao, J.C., Xia, Q., Sun, C., Aili, M., Talifu, A., Huo, S.X., Zhang, Y., Li, Z.J. (2024) Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in pharmacology. 15:13086551308655
- Karolczak, S., Deshwar, A.R., Aristegui, E., Kamath, B.M., Lawlor, M.W., Andreoletti, G., Volpatti, J.R., Ellis, J.L., Yin, C., Dowling, J.J. (2023) Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy. The Journal of Clinical Investigation. 133(18):
- Zhai, W., Wang, Z., Ye, C., Ke, L., Wang, H., Liu, H. (2023) IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish. International Journal of Molecular Sciences. 24(24):
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Zhang, X., Xia, M., Su, X., Yuan, P., Li, X., Zhou, C., Wan, Z., Zou, W. (2021) Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis. Journal of hazardous materials. 413:125321
- Moraes, J.S., da Silva Nornberg, B.F., Castro, M.R., Vaz, B.D.S., Mizuschima, C.W., Marins, L.F.F., Martins, C.M.G. (2020) Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb®. Chemosphere. 248:125959
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Zhao, X., Lorent, K., Escobar-Zarate, D., Rajagopalan, R., Loomes, K.M., Gillespie, K., Mesaros, C., Estrada, M.A., Blair, I., Winkler, J.D., Spinner, N.B., Devoto, M., Pack, M. (2020) Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology. 159(3):1068-1084.e2
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