Gene
polr1c
- ID
- ZDB-GENE-040426-1495
- Name
- RNA polymerase I and III subunit C
- Symbol
- polr1c Nomenclature History
- Previous Names
-
- zgc:65973
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Acts upstream of or within cartilage development; embryonic viscerocranium morphogenesis; and ribosome biogenesis. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Is expressed in several structures, including head; immature eye; midbrain; midbrain hindbrain boundary; and segmental plate. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908483 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 11 | Alliance | Leukodystrophy, hypomyelinating, 11 | 616494 |
| Treacher Collins syndrome 3 | Alliance | Treacher Collins syndrome 3 | 248390 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001514 | DNA-directed RNA polymerase, 30-40kDa subunit, conserved site |
| Domain | IPR011262 | DNA-directed RNA polymerase, insert domain |
| Domain | IPR011263 | DNA-directed RNA polymerase, RpoA/D/Rpb3-type |
| Family | IPR022842 | DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1 |
| Family | IPR033901 | DNA-directed RNA polymerases I and III subunit AC40 |
| Family | IPR050518 | Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit |
| Homologous_superfamily | IPR036603 | RNA polymerase, RBP11-like subunit |
| Homologous_superfamily | IPR036643 | DNA-directed RNA polymerase, insert domain superfamily |
Domain Details Per Protein
| Protein | Length | Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit | DNA-directed RNA polymerase, 30-40kDa subunit, conserved site | DNA-directed RNA polymerase, insert domain | DNA-directed RNA polymerase, insert domain superfamily | DNA-directed RNA polymerase, RpoA/D/Rpb3-type | DNA-directed RNA polymerases I and III subunit AC40 | DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1 | RNA polymerase, RBP11-like subunit |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PHE7
|
347 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr1c-201
(1)
|
Ensembl | 1,323 nt | ||
| mRNA |
polr1c-202
(1)
|
Ensembl | 843 nt |
Interactions and Pathways
No data available
Plasmids
No data available