Gene

slc44a4

ID

ZDB-GENE-040426-1371

Name

solute carrier family 44 member 4

Symbol

slc44a4 Nomenclature History

Previous Names

zgc:64108 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable choline transmembrane transporter activity and thiamine pyrophosphate transmembrane transporter activity. Involved in neuromast hair cell development and otolith formation. Acts upstream of or within otolith development. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; midbrain; olfactory system; otic vesicle; and pronephric duct. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to human SLC44A4 (solute carrier family 44 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64108 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ma et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc44a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 72	Alliance	?Deafness, autosomal dominant 72	617606

Associated With slc44a4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
sensorineural hearing loss	AB + MO2-slc44a4	standard conditions	Ma et al., 2017
sensorineural hearing loss	AB + MO1-slc44a4	standard conditions	Ma et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007603	Choline transporter-like

Domain Details Per Protein

Protein	Length	Choline transporter-like
UniProtKB:Q7T2B0 InterPro	723

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	slc44a4-201 (1) Ensembl	Ensembl		2,112 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations