Gene

fermt3b

ID

ZDB-GENE-040426-1366

Name

FERM domain containing kindlin 3b

Symbol

fermt3b Nomenclature History

Previous Names

kindlin-3 (1)
zgc:64101

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to be involved in integrin-mediated signaling pathway. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (fermitin family member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Pluskota et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fermt3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
leukocyte adhesion deficiency 3	Alliance	Leukocyte adhesion deficiency, type III	612840

Associated With fermt3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR037837	Kindlin/fermitin, PH domain
Domain	IPR040790	Kindlin-2, N-terminal
Family	IPR037843	Kindlin/fermitin
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain